Histone variants: deviants?

被引：272

作者：

Kamakaka, RT ^{[1
]}

Biggins, S

机构：

[1] NIH, UCT, Bethesda, MD 20892 USA

[2] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 03期

关键词：

D O I：

10.1101/gad.1272805

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specific functions. in addition, we review histone variant assembly into chromatin, the structure of the variant chromatin, and post-translational modifications that occur on the variants.

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页码：295 / 310

页数：16

相关论文

共 154 条

[1] Structural characterization of macroH2A containing chromatin [J].

Abbott, DW ;

Laszczak, M ;

Lewis, JD ;

Su, H ;

Moore, SC ;

Hills, M ;

Dimitrov, S ;

Ausió, J .

BIOCHEMISTRY, 2004, 43 (05) :1352-1359

[2] Characterization of the stability and folding of H2A.Z chromatin particles -: Implications for transcriptional activation [J].

Abbott, DW ;

Ivanova, VS ;

Wang, XY ;

Bonner, WM ;

Ausió, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) :41945-41949

[3] H2A.Z is required for global chromatin integrity and for recruitment of RNA polymerase II under specific conditions [J].

Adam, M ;

Robert, F ;

Larochelle, M ;

Gaudreau, L .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (18) :6270-6279

[4] The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly [J].

Ahmad, K ;

Henikoff, S .

MOLECULAR CELL, 2002, 9 (06) :1191-1200

[5] Histone H3 variants specify modes of chromatin assembly [J].

Ahmad, K ;

Henikoff, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 :16477-16484

[6] Centromeres are specialized replication domains in heterochromatin [J].

Ahmad, K ;

Henikoff, S .

JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :101-109

[7] Identification and characterization of the Drosophila histone h4 replacement gene [J].

Akhmanova, A ;

Miedema, K ;

Hennig, W .

FEBS LETTERS, 1996, 388 (2-3) :219-222

[8] Mammalian linker-histone subtypes differentially affect gene expression in vivo [J].

Alami, R ;

Fan, YH ;

Pack, S ;

Sonbuchner, TM ;

Besse, A ;

Lin, QC ;

Greally, JM ;

Skouitchi, AL ;

Bouhassira, EE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :5920-5925

[9]

Albig W, 1996, HUM GENET, V97, P486

[10] The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of MacroH2A [J].

Allen, MD ;

Buckle, AM ;

Cordell, SC ;

Löwe, J ;

Bycroft, M .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 330 (03) :503-511

← 1 2 3 4 5 6 7 8 9 10 →