Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile

被引：15

作者：

Noren, T. ^{[1
]}

Akerlund, T.

Wullt, M.

Burman, L. G.

Unemo, M.

机构：

[1] Univ Orebro Hosp, Dept Infect Dis, SE-70185 Orebro, Sweden

[2] Univ Orebro Hosp, Dept Clin Microbiol, SE-70185 Orebro, Sweden

[3] Dept Clin Sci, Malmo, Sweden

[4] Lund Univ, S-22100 Lund, Sweden

[5] Swedish Inst Infect Dis Control, Solna, Sweden

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 05期

关键词：

D O I：

10.1128/AAC.01283-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.

引用

页码：1840 / 1843

页数：4

共 29 条

[1] Molecular analysis of fusidic acid resistance in Staphylococcus aureus [J].

Besier, S ;

Ludwig, A ;

Brade, V ;

Wichelhaus, TA .

MOLECULAR MICROBIOLOGY, 2003, 47 (02) :463-469

[2] Fusidic acid resistance in Staphylococcus aureus isolates [J].

Brown, EM ;

Thomas, P .

LANCET, 2002, 359 (9308) :803-803

[3] The genome sequence of Clostridium tetani, the causative agent of tetanus disease [J].

Brüggemann, H ;

Bäumer, S ;

Fricke, WF ;

Wiezer, A ;

Liesegang, H ;

Decker, I ;

Herzberg, C ;

Martínez-Arias, R ;

Merkl, R ;

Henne, A ;

Gottschalk, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1316-1321

[4] ANTIBIOTIC SUSCEPTIBILITY OF CLOSTRIDIUM-DIFFICILE [J].

BURDON, DW ;

BROWN, JD ;

YOUNGS, DJ ;

ARABI, Y ;

SHINAGAWA, N ;

ALEXANDERWILLIAMS, J ;

KEIGHLEY, MRB ;

GEORGE, RH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1979, 5 (03) :307-310

[5] FUSIDIC ACID FOR THE TREATMENT OF ANTIBIOTIC-ASSOCIATED COLITIS INDUCED BY CLOSTRIDIUM-DIFFICILE [J].

CRONBERG, S ;

CASTOR, B ;

THOREN, A .

INFECTION, 1984, 12 (04) :276-279

[6] Factors associated with failure of metronidazole in Clostridium difficile-associated disease [J].

Fernandez, A ;

Anand, G ;

Friedenberg, F .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2004, 38 (05) :414-418

[7]

GODTFREDSEN W, 1962, Lancet, V1, P928, DOI 10.1016/S0140-6736(62)91968-2

[8] FUSIDIC ACID-RESISTANT MUTANTS DEFINE 3 REGIONS IN ELONGATION-FACTOR-G OF SALMONELLA-TYPHIMURIUM [J].

JOHANSON, U ;

HUGHES, D .

GENE, 1994, 143 (01) :55-59

[9] The complete genome sequence of the Gram-positive bacterium Bacillus subtilis [J].

Kunst, F ;

Ogasawara, N ;

Moszer, I ;

Albertini, AM ;

Alloni, G ;

Azevedo, V ;

Bertero, MG ;

Bessieres, P ;

Bolotin, A ;

Borchert, S ;

Borriss, R ;

Boursier, L ;

Brans, A ;

Braun, M ;

Brignell, SC ;

Bron, S ;

Brouillet, S ;

Bruschi, CV ;

Caldwell, B ;

Capuano, V ;

Carter, NM ;

Choi, SK ;

Codani, JJ ;

Connerton, IF ;

Cummings, NJ ;

Daniel, RA ;

Denizot, F ;

Devine, KM ;

Dusterhoft, A ;

Ehrlich, SD ;

Emmerson, PT ;

Entian, KD ;

Errington, J ;

Fabret, C ;

Ferrari, E ;

Foulger, D ;

Fritz, C ;

Fujita, M ;

Fujita, Y ;

Fuma, S ;

Galizzi, A ;

Galleron, N ;

Ghim, SY ;

Glaser, P ;

Goffeau, A ;

Golightly, EJ ;

Grandi, G ;

Guiseppi, G ;

Guy, BJ ;

Haga, K .

NATURE, 1997, 390 (6657) :249-256

[10] Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site [J].

Laurberg, M ;

Kristensen, O ;

Martemyanov, K ;

Gudkov, AT ;

Nagaev, I ;

Hughes, D ;

Liljas, A .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 303 (04) :593-603

← 1 2 3 →