Imatinib has a fatal impact on morphology, pairing stability and survival of adult Schistosoma mansoni in vitro

被引：89

作者：

Beckmann, S. ^{[1
]}

Grevelding, C. G. ^{[1
]}

机构：

[1] Univ Giessen, Inst Parasitol, D-35392 Giessen, Germany

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2010年 / 40卷 / 05期

关键词：

Schistosoma mansoni; Abl tyrosine kinase; Gonad development; Gastrodermis; Imatinib; TYROSINE KINASE; PROTEIN-KINASES; EXPRESSION; TARGETS; ABL;

D O I：

10.1016/j.ijpara.2010.01.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

Schistosomes cause bilharzia (schistosomiasis), one of the most prevalent parasitic diseases for human and animals worldwide. Praziquantel (PZQ) is the only widely used drug for treatment and control of this parasitemia. Since a vaccine is not yet available, and in light of emerging resistance against PZQ, the search for alternatives has high priority. Here we present that Imatinib, a compound used in human cancer therapy (Gleevec; STI-571), significantly affected schistosome morphology and physiology in vitro. Besides its negative effect on gonad development and pairing stability, Imatinib led to pathological alterations of the gastrodermis, which finally caused the death of the parasite. (C) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：521 / 526

页数：6

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