Maturation of eukaryotic ribosomes: acquisition of functionality

被引：154

作者：

Panse, Vikram Govind ^{[1
]}

Johnson, Arlen W. ^{[2
]}

机构：

[1] ETH, Inst Biochem IBC, CH-8093 Zurich, Switzerland

[2] Univ Texas Austin, Sect Mol Genet & Microbiol, Inst Cellular & Mol Biol, Austin, TX 78712 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2010年 / 35卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

NUCLEAR EXPORT RECEPTOR; CYTOPLASMIC MATURATION; PRERIBOSOMAL FACTORS; SUBUNIT REQUIRES; PRE-RIBOSOMES; 60S SUBUNIT; PROTEIN; RNA; BIOGENESIS; LOCALIZATION;

D O I：

10.1016/j.tibs.2010.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotic cells, ribosomes are pre-assembled in the nucleus and exported to the cytoplasm where they undergo final maturation. This involves the release of trans-acting shuttling factors, transport factors, incorporation of the remaining ribosomal proteins, and final rRNA processing steps. Recent work, particularly on the large (60S) ribosomal subunit, has confirmed that the 60S subunit is exported from the nucleus in a functionally inactive state. Its arrival in the cytoplasm triggers events that render it translationally competent. Here we focus on these cytoplasmic maturation events and speculate why eukaryotic cells have evolved such an elaborate maturation pathway.

引用

页码：260 / 266

页数：7

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