Role of GTPases in Bacterial Ribosome Assembly

被引：136

作者：

Britton, Robert A. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2009年 / 63卷

基金：

美国国家科学基金会;

关键词：

translation; 50S subunit; 30S subunit; biogenesis; assembly factor; GTP-BINDING PROTEIN; GUANINE-NUCLEOTIDE-BINDING; BACILLUS-SUBTILIS GTPASE; CELL-CYCLE ARREST; ESCHERICHIA-COLI; DNA-REPLICATION; SMALL-SUBUNIT; GROWTH-RATE; RNA; ERA;

D O I：

10.1146/annurev.micro.091208.073225

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The assembly of the ribosome,a complex molecular machine composed of RNA and protein, is a poorly, understood process. Recent work his demonstrated that GTPases are likely to play key roles in the assembly of ribosomes in bacteria and eukaryotes. This review highlights several bacterial ribosome assembly GTPases (RA-GTPases) and discusses possible functions for these proteins in the biogenesis of individual ribosomal subunits and subunit joining. RA-GTPases appear to link various aspects of the cell cycle and metabolism with translation. How these RA-GTPases may coordinate these connections are discussed.

引用

页码：155 / 176

页数：22

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