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Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs

被引：278
作者：
Fredholm, BB [1 ]
Chen, JF
Masino, SA
Vaugeois, JM
机构：
[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
[2] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
[3] Trinity Coll, Dept Psychol, Hartford, CT 06106 USA
[4] Trinity Coll, Neurosci Program, Hartford, CT 06106 USA
[5] Fac Med & Pharm, CNRS, FRE2735, IFRMP 23, F-76183 Rouen, France
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2005年 / 45卷
关键词：
A1; receptor; A2A receptor; caffeine; ischemia; Parkinson's disease; pain;
D O I：
10.1146/annurev.pharmtox.45.120403.095731
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adenosine and its receptors have been the topic of many recent reviews (1-26). These reviews provide a good summary of much of the relevant literature-including the older literature. We have, therefore, chosen to focus the present review on the insights gained from recent studies on genetically modified mice, particularly with respect to the function of adenosine receptors and their potential as therapeutic targets. The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted.
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收藏
页码：385 / 412
页数：28
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