Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin

被引：31

作者：

Kanellakopoulou, K

Galanakis, N

Giamarellos-Bourboulis, EJ

Rifiotis, C

Papakostas, K

Andreopoulos, A

Dounis, E

Karagianakos, P

Giamarellou, H

机构：

[1] Athens Med Sch, Dept Internal Med 4, Athens, Greece

[2] Nikaia Gen Hosp, Dept Internal Med 2, Athens, Greece

[3] Athens Med Sch, Dept Propaedeut Med 1, Athens, Greece

[4] Athens Laiko Gen Hosp, Dept Orthopaed, Athens, Greece

[5] Natl Polytech Sch, Dept Chem Engn, Athens, Greece

[6] Athens Med Sch, Dept Expt Surg, Athens, Greece

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 46卷 / 02期

关键词：

D O I：

10.1093/jac/46.2.311

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A novel biodegradable system of D-,L-dilactide delivering pefloxacin was implanted in 104 rabbits with experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as controls. Animals were killed on each third day and viable bacterial counts and levels of pefloxacin in bone tissue were determined. A 99.9% decrease in viable count of bacteria was achieved by day 12 and complete bacterial eradication on day 33. Pefloxacin was released gradually, reaching its peak on day 15 at levels 100 times the MIC of pefloxacin for MRSA. The biodegradable system described may have a future role in the therapeutic approach to osteomyelitis.

引用

页码：311 / 314

页数：4

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