The dopamine D2 receptor (DRD2) gene -: a genetic risk factor in heavy smoking?

被引：18

作者：

Batra, A

Gelfort, G

Bartels, M

Smoltczyk, H

Buchkremer, G

Riess, O

Schöls, L

机构：

[1] Univ Tubingen, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany

[2] Ruhr Univ Bochum, D-4630 Bochum, Germany

[3] Univ Rostock, Childrens Hosp, Dept Med Genet, Rostock, Germany

[4] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, D-4630 Bochum, Germany

来源：

ADDICTION BIOLOGY | 2000年 / 5卷 / 04期

关键词：

D O I：

10.1111/j.1369-1600.2000.tb00212.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Indications of a genetic predisposition to nicotine dependence have been derived from numerous epidemiological data and from individual genetic studies suggesting the involvement of the dopaminergic D2 receptor. Previous association studies defined the TaqlA polymorphism as a risk factor for addiction, in particular for alcoholism and tobacco dependence. Results of investigations into this polymorphism in 110 severely addicted smokers and a control group of 60 population-matched Ger man non-smokers did not support these findings. However, our results indicate an association between the DRD2-Fokl-1 allele and the onset and intensity of smoking.

引用

页码：429 / 436

页数：8

共 48 条

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