Zfx: At the crossroads of survival and self-renewal

被引：23

作者：

Cellot, Sonia

Sauvageau, Guy

机构：

[1] IRIC, Lab Mol Genet Stem Cells, Montreal, PQ H3C 3J7, Canada

[2] Maisonneuve Rosemont Hosp, Dept Med, Montreal, PQ H3C 3J7, Canada

[3] Maisonneuve Rosemont Hosp, Div Hematol & Leukemia Cell Bank Quebec, Montreal, PQ H3C 3J7, Canada

来源：

CELL | 2007年 / 129卷 / 02期

关键词：

D O I：

10.1016/j.cell.2007.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the molecular mechanisms that govern stem cell fate are beginning to be unraveled, Galan-Caridad et al. (2007) report in this issue of Cell a common role for the transcription factor Zfx in the self-renewal/maintenance of both embryonic stem cells and hematopoietic stem cells. Their work suggests that a regulator of self-renewal can be shared between two different cell types.

引用

页码：239 / 241

页数：3

共 8 条

[1] Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation
Carlson, H
Ota, S
Song, YS
Chen, YW
Hurlin, PJ
[J]. ONCOGENE, 2002, 21 (24) : 3827 - 3835
[2] Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival
Hock, H
Meade, E
Medeiros, S
Schindler, JW
Valk, PJM
Fujiwara, Y
Orkin, SH
[J]. GENES & DEVELOPMENT, 2004, 18 (19) : 2336 - 2341
[3] Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
Hock, H
Hamblen, MJ
Rooke, HM
Schindler, JW
Saleque, S
Fujiwara, Y
Orkin, SH
[J]. NATURE, 2004, 431 (7011) : 1002 - 1007
[4] Dissecting self-renewal in stem cells with RNA interference
Ivanova, Natalia
Dobrin, Radu
Lu, Rong
Kotenko, Iulia
Levorse, John
DeCoste, Christina
Schafer, Xenia
Lun, Yi
Lemischka, Ihor R.
[J]. NATURE, 2006, 442 (7102) : 533 - 538
[5] Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
Lessard, J
Sauvageau, G
[J]. NATURE, 2003, 423 (6937) : 255 - 260
[6] Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
Park, IK
Qian, DL
Kiel, M
Becker, MW
Pihalja, M
Weissman, IL
Morrison, SJ
Clarke, MF
[J]. NATURE, 2003, 423 (6937) : 302 - 305
[7] TANAKA Y, 2007, IN PRESS BLOOD
[8] FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Tothova, Zuzana
Kollipara, Ramya
Huntly, Brian J.
Lee, Benjamin H.
Castrillon, Diego H.
Cullen, Dana E.
McDowell, Elizabeth P.
Lazo-Kallanian, Suzan
Williams, Ifor R.
Sears, Christopher
Armstrong, Scott A.
Passegue, Emmanuelle
DePinho, Ronald A.
Gilliland, D. Gary
[J]. CELL, 2007, 128 (02) : 325 - 339

← 1 →