Fusobacterium and Enterobacteriaceae: Important players for CRC?

被引：129

作者：

Allen-Vercoe, Emma ^{[1
]}

Jobin, Christian ^{[2
,3
]}

机构：

[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON N1G 2W1, Canada

[2] Univ Florida, Dept Med, Gainesville, FL 32611 USA

[3] Univ Florida, Dept Infect Dis & Pathol, Gainesville, FL 32611 USA

来源：

IMMUNOLOGY LETTERS | 2014年 / 162卷 / 02期

关键词：

Microbiome; Cancer; Intestine; Inflammation; INFLAMMATORY-BOWEL-DISEASE; INVASIVE ESCHERICHIA-COLI; CROHNS-DISEASE; STREPTOCOCCUS-CRISTATUS; GUT MICROBIOTA; ILEAL MUCOSA; HOST-MICROBIOTA; PANETH CELLS; NUCLEATUM; CANCER;

D O I：

10.1016/j.imlet.2014.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities ranging from barrier, immunity and metabolic function. Not surprisingly, microbial dysbiosis is associated with numerous intestinal disorders including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). In this piece, we will review recent evidence that gut microbial dysbiosis can influence intestinal disease, including colitis and CRC. We will discuss the biological events implicated in the development of microbial dysbiosis and the emergence of CRC-associated microorganisms, focusing on Escherichia coli and Fusobacterium nucleatum. Finally, the mechanisms by which E. coli and F. nucleatum exert potentially carcinogenic effects on the host will be reviewed. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：54 / 61

页数：8

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