The Mechanism in Gastric Cancer Chemoprevention by Allicin

被引：51

作者：

Luo, Runlan ^{[1
]}

Fang, Dengyang ^{[1
]}

Hang, Hongdong ^{[2
]}

Tang, Zeyao ^{[1
]}

机构：

[1] Dalian Med Univ, Dept Pharmacol, 9 West Sect,South Rd Lushun, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Hosp 1, Dept Internal Med, Dalian 116044, Peoples R China

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 07期

关键词：

Allicin; gastric cancer; cell phase arrest; apoptosis; anticancer; HELICOBACTER-PYLORI INFECTION; SIGNAL-REGULATED KINASE; CELL-CYCLE ARREST; DIALLYL DISULFIDE; IN-VITRO; OXIDATIVE STRESS; ALLYL SULFIDES; CARCINOMA-CELLS; UP-REGULATION; APOPTOSIS;

D O I：

10.2174/1871520616666151111115443

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Gastric cancer remains high prevalence and fatality rates in China even though its morbidity has been decreased drastically. Allicin, which is from an assistance food-garlic (Allium Sativum L), was found to be effective in gastric cancer treatment. It is a defensive substance with a board biological properties: inhibition of bacteria, fungus, virus, controlled hypertension, diabetes, and chemoprevention of several cancers, etc. Experiments have shown that allicin can be chemopreventive to gastric cancer by inhibiting the growth of cancer cells, arresting cell cycle at G2/M phase, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis, which includes the caspase-dependent/-independent pathways and death receptor pathway. Those mechanisms probably involve in modulating enzymatic activity, restraining DNA formation, scavenging free radicals, and affecting cell proliferation and even tumor growth. Therefore, this review is focus on the mechanism of allicin in gastric cancer.

引用

页码：802 / 809

页数：8

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