Distribution of P2X purinoceptor clusters on individual rat dorsal root ganglion cells

被引：24

作者：

Barden, JA

Bennett, MR ^{[1
]}

机构：

[1] Univ Sydney, Inst Biomed Res, Dept Physiol, Neurobiol Lab, Sydney, NSW 2006, Australia

[2] Univ Sydney, Inst Biomed Res, Dept Anat & Histol, Prot Receptor Struct Lab, Sydney, NSW 2006, Australia

来源：

NEUROSCIENCE LETTERS | 2000年 / 287卷 / 03期

关键词：

sensory neurons; purinoceptors; P2X clusters;

D O I：

10.1016/S0304-3940(00)01150-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of P2X receptors on the cell bodies of acutely dissociated rat dorsal root ganglion cells has been determined using immunohistochemistry. Only medium and small ganglion cells showed P2X receptor labelling, which took the form of receptor clusters 0.2-0.5 mu m in diameter. P2X(3) was the predominant cluster type although clusters of all other subtypes, P2X(1), P2X(2), P2X(4), P2X(5) and P2X(6) were observed. There was little evidence for colocalization of the different receptor subtypes pointing to very little heteropolymerization of P2X receptors in the ganglion. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：183 / 186

页数：4

共 21 条

[1] Vesicle-associated proteins and P2X receptor clusters at single sympathetic varicosities in mouse vas deferens [J].