Delivery of retinoid-based therapies to target tissues

被引:63
作者
Moise, Alexander R. [1 ]
Noy, Noa
Palczewski, Krzysztof
Blaner, William S.
机构
[1] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA
[2] Columbia Univ Coll Phys & Surg, Inst Human Nutr, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
关键词
D O I
10.1021/bi7003069
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Through its various metabolites, vitamin A controls essential physiological functions. Both naturally occurring metabolites and novel retinoid analogues have shown effectiveness in many clinical settings that include skin diseases and cancer, and in animal models of human conditions affecting vision. In this review, we analyze several potential retinoid-based therapies from the point of view of drug metabolism and transport to target tissues. We focus on the endogenous factors that affect the absorption, transport, and metabolism of retinoids by taking into account data obtained from the analysis of animal models that lack the enzymes or proteins involved in the storage and absorption of retinoids. We also discuss findings of toxicity associated with retinoids in an effort to improve the outcome of retinoid-based therapies. In this context, we review evidence that esterification of retinol and retinol-based drugs within target tissues provides one of the most efficient means to improve the absorption and to reduce the toxicity associated with pharmacological doses of retinoids. Future retinoid-based therapeutic strategies could involve targeted delivery mechanisms leading to lower toxicity and improved effectiveness of retinoids.
引用
收藏
页码:4449 / 4458
页数:10
相关论文
共 139 条
[1]   What is the best approach to reducing birth defects associated with isotretinoin? [J].
Abroms, Lorien ;
Maibach, Edward ;
Lyon-Daniel, Katherine ;
Feldman, Steven R. .
PLOS MEDICINE, 2006, 3 (11) :1978-1983
[2]   Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer [J].
Arapshian, Alice ;
Bertran, Silvina ;
Kuppumbatti, Yuvarani S. ;
Nakajo, Shigeo ;
Mira-y-Lopez, Rafael .
MOLECULAR CANCER, 2004, 3 (1)
[3]   Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of leber congenital amaurosis [J].
Batten, ML ;
Imanishi, Y ;
Tu, DC ;
Doan, T ;
Zhu, L ;
Pang, JJ ;
Glushakova, L ;
Moise, AR ;
Baehr, W ;
Van Gelder, RN ;
Hauswirth, WW ;
Rieke, F ;
Palczewski, K .
PLOS MEDICINE, 2005, 2 (11) :1177-1189
[4]   Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver [J].
Batten, ML ;
Imanishi, Y ;
Maeda, T ;
Tu, DC ;
Moise, AR ;
Bronson, D ;
Possin, D ;
Van Gelder, RN ;
Baehr, W ;
Palczewski, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (11) :10422-10432
[5]  
BAXI SC, 1982, WESTERN J MED, V137, P429
[6]   A RANDOMIZED TRIAL OF VITAMIN-A AND VITAMIN-E SUPPLEMENTATION FOR RETINITIS-PIGMENTOSA [J].
BERSON, EL ;
ROSNER, B ;
SANDBERG, MA ;
HAYES, KC ;
NICHOLSON, BW ;
WEIGELDIFRANCO, C ;
WILLETT, W .
ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (06) :761-772
[7]   STRA6, a cell-surface receptor for retinol-binding protein: The plot thickens [J].
Blaner, William S. .
CELL METABOLISM, 2007, 5 (03) :164-166
[8]  
BLANER WS, 1985, J LIPID RES, V26, P1241
[9]  
BLANER WS, 1994, J BIOL CHEM, V269, P16559
[10]  
BLANER WS, 1994, RETINOIDS BIOL CHEM