Antimalarial activity of Lactucin and Lactucopicrin:: sesquiterpene lactones isolated from Cichorium intybus L.

被引：139

作者：

Bischoff, TA ^{[1
]}

Kelley, CJ

Karchesy, Y

Laurantos, M

Nguyen-Dinh, P

Arefi, AG

机构：

[1] Massachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA

[2] Massachusetts Coll Pharm & Allied Hlth Sci, Heber Younken Pharmacognosy Lab, Boston, MA 02115 USA

[3] Ctr Dis Control & Prevent, Div Parasit Dis, Biol & Diagnost Branch, Atlanta, GA 30333 USA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 95卷 / 2-3期

关键词：

Cichorium intybus; lactucin; lactucopicrin; antimalarial; plasmodium;

D O I：

10.1016/j.jep.2004.06.031

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodiumfalciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactueopicrin to be antimalarial compounds. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：455 / 457

页数：3

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