Highly enantioselective Friedel-Crafts alkylations of indoles with simple enones catalyzed by zirconium(IV)-BINOL complexes

被引：123

作者：

Blay, Gonzalo ^{[1
]}

Fernandez, Isabel ^{[1
]}

Pedro, Jose R. ^{[1
]}

Vila, Carlos ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, E-46100 Burjassot, Spain

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 13期

关键词：

D O I：

10.1021/ol0710820

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Complexes of BINOL-based ligands with Zr((OBu)-Bu-t)(4) catalyze the Friedel-Crafts alkylation reaction of indoles and pyrrole with nonchelating beta-substituted alpha,beta-enones at room temperature affording the expected products with good yields and ee above 95% in most of the studied examples.

引用

页码：2601 / 2604

页数：4

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