Enantioselective allylation of aromatic amines after in situ generation of an activated cyclometalated iridium catalyst

被引：175

作者：

Shu, CT ^{[1
]}

Leitner, A ^{[1
]}

Hartwig, JF ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 36期

关键词：

allylations; aminations; asymmetric catalysis; iridium regioselectivity;

D O I：

10.1002/anie.200460276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly regio- and enantioselective allylation of aromatic amines is observed when a cyclometalated Ir-phosphoramidite complex is generated in situ (see scheme). The active catalyst can be formed from [{Ir(cod)Cl}2] and ligand L with a volatile alkylamine prior to addition of the reagents or upon use of a tertiary amine additive.

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页码：4797 / 4800

页数：4

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