Trimethylsilyl chloride:: A facile and efficient reagent for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

被引：56

作者：

Zhu, YL ^{[1
]}

Pan, YJ ^{[1
]}

Huang, SL ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 17期

关键词：

Biginelli reaction; trimethylsilyl chloride; Lewis acid; 3,4-dihydropyrimidin-2(1H)-ones;

D O I：

10.1081/SCC-200028607

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trimethylsilyl chloride (TMSCl) was used as a Lewis acid to efficiently perform one-pot, three-components, Biginelli condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and urea or thiourea. This resulted in simple one-pot synthesis of the corresponding 3,4-dihydropyrimidin-2(1H)-ones at room temperature with excellent yield.

引用

页码：3167 / 3174

页数：8

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