The GB virus C/hepatitis G virus replicates in hepatocytes without causing liver disease in healthy blood donors

被引：16

作者：

Halasz, R

Sällberg, M

Lundholm, S

Andersson, G

Lager, B

Glaumann, H

Weiland, O ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Div Infect Dis I 73, Dept Med, S-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Div Clin Virol, S-14186 Huddinge, Sweden

[3] Huddinge Univ Hosp, Karolinska Inst, Div Pathol, S-14186 Huddinge, Sweden

[4] Huddinge Univ Hosp, Karolinska Inst, Div Transfus Med, S-14186 Huddinge, Sweden

来源：

JOURNAL OF INFECTIOUS DISEASES | 2000年 / 182卷 / 06期

关键词：

D O I：

10.1086/317610

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thirty-seven persons were identified with GB virus C (GBV-C) single infection by polymerase chain reaction screening of 1254 healthy blood donors. Of 33 donors who returned for clinical examination, 17 underwent liver biopsy. Clinical, biochemical, and histologic evaluation did not reveal any signs of liver disease. Liver biopsies of 15 donors were analyzed by in situ hybridization with GBV-C RNA probes and immunologic staining for the GBV-C envelope 2 protein. GBV-C replication was identified in the cytoplasm of hepatocytes of 10 (67%) donor livers but in none of 7 liver biopsies of chronic hepatitis B virus carriers negative for serum GBV-C RNA. Thus, there was no evidence of liver disease in GBV-C-infected healthy blood donors despite viral replication in hepatocytes.

引用

页码：1756 / 1760

页数：5

共 24 条

[21] Heterosexual transmission of GB virus-C hepatitis G virus infection [J].