Functionalized fluorescent oxide nanoparticles: Artificial toxins for sodium channel targeting and Imaging at the single-molecule level

被引：171

作者：

Beaurepaire, E

Buissette, V

Sauviat, MP

Giaume, D

Lahlil, K

Mercuri, A

Casanova, D

Huignard, A

Martin, JL

Gacoin, T

Boilot, JP

Alexandrou, A ^{[1
]}

机构：

[1] Ecole Polytech, ENSTA, INSERM,Lab Opt & Biosci, U451,CNRS,UMR 7645, F-91128 Palaiseau, France

[2] Ecole Polytech, CNRS, UMR 7641,Solid State Chem Grp, Condensed Matter Phys Lab, F-91128 Palaiseau, France

来源：

NANO LETTERS | 2004年 / 4卷 / 11期

关键词：

D O I：

10.1021/nl049105g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lanthanide ion-doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water, which facilitates their functionalization, and are remarkably photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in live cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear to be a novel tool that is particularly attractive for long-term single-molecule tracking.

引用

页码：2079 / 2083

页数：5

共 27 条

[1] On-off blinking and multiple bright states of single europium ions in Eu3+:Y2O3 nanocrystals [J].