Adhesion-linked kinases in cancer; emphasis on Src, focal adhesion kinase and PI 3-kinase

被引：97

作者：

Jones, RJ ^{[1
]}

Brunton, VG ^{[1
]}

Frame, MC ^{[1
]}

机构：

[1] Beatson Inst Canc Res, CRC Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 13期

关键词：

Src; focal adhesion kinase (FAK); phosphatidylinositol 3-kinase (PI 3-kinase) adhesion; cell signalling;

D O I：

10.1016/S0959-8049(00)00153-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our understanding of the complex signal transduction pathways involved in signalling within cancer cells, between cancer cells and between cancer cells and their environment has increased dramatically in recent years. Here we concentrate on three nonreceptor kinases: Src, focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI 3-kinase). These form part of a complex network of intracellular signals which is thought to be important in regulating cancer cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1595 / 1606

页数：12

共 133 条

[1] Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells [J].

Agochiya, M ;

Brunton, VG ;

Owens, DW ;

Parkinson, EK ;

Paraskeva, C ;

Keith, WN ;

Frame, MC .

ONCOGENE, 1999, 18 (41) :5646-5653

[2] FOCAL ADHESION KINASE (P125(FAK)) EXPRESSION CORRELATES WITH MOTILITY OF HUMAN-MELANOMA CELL-LINES [J].

AKASAKA, T ;

VANLEEUWEN, RL ;

YOSHINAGA, IG ;

MIHM, MC ;

BYERS, HR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (01) :104-108

[3] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[4] Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity [J].

Ali, IU ;

Schriml, LM ;

Dean, M .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22) :1922-1932

[5] Role of translocation in the activation and function of protein kinase B [J].

Andjelkovic, M ;

Alessi, DR ;

Meier, R ;

Fernandez, A ;

Lamb, NJC ;

Frech, M ;

Cron, P ;

Cohen, P ;

Lucocq, JM ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31515-31524

[6] EXPRESSION OF AN N-TERMINALLY TRUNCATED FORM OF HUMAN FOCAL ADHESION KINASE IN BRAIN [J].

ANDRE, E ;

BECKERANDRE, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (01) :140-147

[7] A RETROVIRAL ONCOGENE, AKT, ENCODING A SERINE-THREONINE KINASE CONTAINING AN SH2-LIKE REGION [J].

BELLACOSA, A ;

TESTA, JR ;

STAAL, SP ;

TSICHLIS, PN .

SCIENCE, 1991, 254 (5029) :274-277

[8] Src and Ras are involved in separate pathways in epithelial cell scattering [J].

Boyer, B ;

Roche, S ;

Denoyelle, M ;

Thiery, JP .

EMBO JOURNAL, 1997, 16 (19) :5904-5913

[9] A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer [J].

Brunton, VG ;

Ozanne, BW ;

Paraskeva, C ;

Frame, MC .

ONCOGENE, 1997, 14 (03) :283-293

[10] TYROSINE PHOSPHORYLATION OF PAXILLIN AND PP125(FAK) ACCOMPANIES CELL-ADHESION TO EXTRACELLULAR-MATRIX - A ROLE IN CYTOSKELETAL ASSEMBLY [J].

BURRIDGE, K ;

TURNER, CE ;

ROMER, LH .

JOURNAL OF CELL BIOLOGY, 1992, 119 (04) :893-903

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