Adhesion-linked kinases in cancer; emphasis on Src, focal adhesion kinase and PI 3-kinase

被引：97

作者：

Jones, RJ ^{[1
]}

Brunton, VG ^{[1
]}

Frame, MC ^{[1
]}

机构：

[1] Beatson Inst Canc Res, CRC Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 13期

关键词：

Src; focal adhesion kinase (FAK); phosphatidylinositol 3-kinase (PI 3-kinase) adhesion; cell signalling;

D O I：

10.1016/S0959-8049(00)00153-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our understanding of the complex signal transduction pathways involved in signalling within cancer cells, between cancer cells and between cancer cells and their environment has increased dramatically in recent years. Here we concentrate on three nonreceptor kinases: Src, focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI 3-kinase). These form part of a complex network of intracellular signals which is thought to be important in regulating cancer cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1595 / 1606

页数：12

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