H2O2 renders cells accessible to lysis by exogenous phospholipase A(2): A novel mechanism for cell damage in inflammatory processes

被引：43

作者：

Dan, P

Nitzan, DW

Dagan, A

Ginsburg, I

Yedgar, S

机构：

[1] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT BIOCHEM, IL-91120 JERUSALEM, ISRAEL

[2] HEBREW UNIV JERUSALEM, HADASSAH SCH DENT MED, DEPT MAXILLOFACIAL SURG, IL-91120 JERUSALEM, ISRAEL

[3] HEBREW UNIV JERUSALEM, HADASSAH SCH DENT MED, DEPT ORAL BIOL, IL-91120 JERUSALEM, ISRAEL

来源：

FEBS LETTERS | 1996年 / 383卷 / 1-2期

关键词：

phospholipase A(2); H2O2; cell surface proteoglycan; inflammation;

D O I：

10.1016/0014-5793(96)00227-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipase A(2) (PLA(2)) and H2O2, secreted from activated inflammatory cells, play a central role in the tissue damage occurring in inflammatory processes. However, while exogenous PLA(2) alone does not cause cell lysis, it readily does so when acting with H2O2. We have found that H2O2 degrades cell surface proteoglycans, thus rendering the membrane PL accessible to hydrolysis by exogenous PLA(2). This novel mechanism introduces a role for cell surface proteoglycans in protection of cells from damage by pro-inflammatory agents, and may assign a central role for the combined action of H2O2 and PLA(2) in inflammatory and bacteriocidal processes.

引用

页码：75 / 78

页数：4

共 28 条

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