Navigated transcranial magnetic stimulation does not decrease the variability of motor-evoked potentials

被引:109
作者
Jung, Nikolai H.
Delvendahl, Igor
Kuhnke, Nicola G.
Hauschke, Dieter [2 ]
Stolle, Sabine
Mall, Volker [1 ]
机构
[1] Univ Med Ctr Freiburg, Dept Paediat & Adolescent Med, Dept Neuropaediat & Muscular Disorders, Div Neuropaediat & Muscular Disorders, Freiburg, Germany
[2] Univ Med Ctr Freiburg, Dept Med Biometry & Med Informat, Freiburg, Germany
关键词
transcranial magnetic stimulation; navigation; variability; CORTICAL EXCITABILITY; CORTICOSPINAL EXCITABILITY; STIMULUS-INTENSITY; IFCN COMMITTEE; CORTEX; PLASTICITY; MUSCLE; BRAIN; PULSE; ACTIVATION;
D O I
10.1016/j.brs.2009.10.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Background One maim attribute of transcranial magnetic stimulation (TMS) is the variability of motor-evoked potential (MEP) amplitudes. to which variations of coil positioning may contribute Navigated TMS allows the investigator to net a stimulation site with an accuracy of 2 5 mm and to retain position with low spatial divergence during stimulation Objective The purpose of this study was to investigate whether increased spatial constancy of the cod using, a navigational system decreases the variability of MEP amplitudes and increases their reproducibility between different points in time of investigation Methods We investigated eight healthy subjects (mean age 23 8 +/- 1 2 years. range 22-25. four women, foul men) at three different points in time with and without an optically tracked frameless navigational device, respectively Input-output curves, motor threshold. and MEP amplitudes were recorded We calculated the coefficient of variation as statistical parameter of variability Reproducibility between different sessions was assessed via the MEP amplitude Results The coefficient of variance of MEP amplitudes did not show a distinct difference between navigated and non-navigated TMS in input-output curves MEP amplitudes. indicating reproducibility. did not significantly differ between sessions with and without navigated TMS. either Conclusions Our results do not support the hypothesis that increased spatial constancy using a navigational system improves variability and reproducibility of MEP amplitudes Variability of MEN might mainly be due to not influenceable neurophysiologic factors such as undulant cortical excitability and spinal desynchronization (C) 2010 Elsevier Inc All rights reserved.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 41 条
[1]
Possible origins of the complex topographic organization of motor cortex: Reduction of a multidimensional space onto a two-dimensional array [J].
Aflalo, Tyson N. ;
Graziano, Michael S. A. .
JOURNAL OF NEUROSCIENCE, 2006, 26 (23) :6288-6297
[2]
OPTIMAL FOCAL TRANSCRANIAL MAGNETIC ACTIVATION OF THE HUMAN MOTOR CORTEX - EFFECTS OF COIL ORIENTATION, SHAPE OF THE INDUCED CURRENT PULSE, AND STIMULUS-INTENSITY [J].
BRASILNETO, JP ;
COHEN, LG ;
PANIZZA, M ;
NILSSON, J ;
ROTH, BJ ;
HALLETT, M .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1992, 9 (01) :132-136
[3]
Chen R, 2000, MUSCLE NERVE, pS26
[4]
The clinical diagnostic utility of transcranial magnetic stimulation: Report of an IFCN committee [J].
Chen, Robert ;
Cros, Didier ;
Curra, Antonio ;
Di Lazzaro, Vincenzo ;
Lefaucheur, Jean-Pascal ;
Magistris, Michel R. ;
Mills, Kerry ;
Roesler, Kai M. ;
Triggs, William J. ;
Ugawa, Yoshikazu ;
Ziemann, Ulf .
CLINICAL NEUROPHYSIOLOGY, 2008, 119 (03) :504-532
[5]
Navigated transcranial magnetic stimulation and computed electric field strength reduce stimulator-dependent differences in the motor threshold [J].
Danner, Nils ;
Julkunen, Petro ;
Kononen, Mervi ;
Saisanen, Laura ;
Nurkkala, Jouko ;
Karhu, Jari .
JOURNAL OF NEUROSCIENCE METHODS, 2008, 174 (01) :116-122
[6]
Variability of motor potentials evoked by transcranial magnetic stimulation depends on muscle activation [J].
Darling, Warren G. ;
Wolf, Steven L. ;
Butler, Andrew J. .
EXPERIMENTAL BRAIN RESEARCH, 2006, 174 (02) :376-385
[7]
Dunnewold RJW, 1998, MUSCLE NERVE, V21, P1779, DOI 10.1002/(SICI)1097-4598(199812)21:12<1779::AID-MUS23>3.3.CO
[8]
2-F
[9]
Ettinger G J, 1998, Med Image Anal, V2, P133, DOI 10.1016/S1361-8415(98)80008-X
[10]
A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition [J].
Fitzgerald, Paul B. ;
Fountain, Sarah ;
Daskalakis, Zafiris J. .
CLINICAL NEUROPHYSIOLOGY, 2006, 117 (12) :2584-2596