Noise considerations in the determination of diffusion tensor anisotropy

被引:114
作者
Skare, S [1 ]
Li, TQ
Nordell, B
Ingvar, M
机构
[1] Karolinska Inst, MR Ctr, Stockholm, Sweden
[2] Karolinska Inst, Dept Med Radiat Phys, Stockholm, Sweden
[3] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
关键词
diffusion tensor imaging; anisotropy index; noise sensitivity;
D O I
10.1016/S0730-725X(00)00153-3
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In this study the noise sensitivity of various anisotropy indices has been investigated by Monte-Carlo computer simulations and magmetic resonance imaging (MRI) measurements in a phantom and 5 healthy volunteers. Particularly, we compared the noise performance of indices defined solely in terms of eigenvalues and those based on both the eigenvalues and eigenvectors.,It is found that anisotropy indices based on both eigenvalues and eigenvectors are less sensitive to noise, and spatial averaging with neighboring pixels can further reduce the standard deviation. To reduce the partial volume effect caused by the spatial averaging with neighboring voxels, an averaging method in the time domain based on the orientation coherence of eigenvectors in repeated experiments has been proposed. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:659 / 669
页数:11
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