In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis

被引：81

作者：

Tapondjou, LA

Lontsi, D

Sondengam, BL

Choi, JW

Lee, KT

Jung, HJ

Park, HJ ^{[1
]}

机构：

[1] Sangji Univ, Div Appl Plant Sci, Wonju 220702, South Korea

[2] Univ Dschang, Fac Sci, Dept Chem, Dschang, Cameroon

[3] Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon

[4] Kyungsung Univ, Coll Pharm, Pusan 609735, South Korea

[5] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 02期

关键词：

Cussonia bancoensis; triterpenes; ursolic acid; 23-hydroxyursolic acid; anti-nociceptive; anti-inflammatory;

D O I：

10.1007/BF02976660

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the antinociceptive and anti-inflammatory effect of C. bancoesnsis.

引用

页码：143 / 146

页数：4

共 15 条

[1]

Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals [J].