Water enables direct use of allyl alcohol for Tsuji-Trost reaction without activators

被引：235

作者：

Kinoshita, H

Shinokubo, H

Oshima, K

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 22期

关键词：

D O I：

10.1021/ol048207a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An aqueous biphasic reaction system enables the direct use of allyl alcohol in the Tsuji-Trost reaction without the help of any activating reagents for allyl alcohol. The reaction conditions are neutral to basic, allowing the use of amines as the nucleophile. Theoretical calculations have elucidated the importance of hydration of the hydroxy group for the smooth generation of pi-allylpalladium species.

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页码：4085 / 4088

页数：4

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