ENANTIOSPECIFIC SYNTHESIS OF 17-HYDROXYEICOSATETRAENOIC AND 18-HYDROXYEICOSATETRAENOIC ACIDS, CYTOCHROME-P450 ARACHIDONATE METABOLITES

被引：34

作者：

FALCK, JR

LUMIN, S

LEE, SG

HECKMANN, B

MIOSKOWSKI, C

KARARA, A

CAPDEVILA, J

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PHARMACOL,DALLAS,TX 75235

[2] UNIV LOUIS PASTEUR,CNRS,SYNTH BIOORGAN LAB,F-67401 ILLKIRCH GRAFFENS,FRANCE

[3] VANDERBILT UNIV,MED CTR,DEPT MED,NASHVILLE,TN 37232

[4] VANDERBILT UNIV,MED CTR,DEPT CHEM & BIOCHEM,NASHVILLE,TN 37232

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)61226-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title bioactive eicosanoids were prepared from dimethyl L-malate by a convergent strategy exploiting the differential reactivity of ethereal dialkylcuprates towards tosylates versus bromides.

引用

页码：4893 / 4896

页数：4

共 21 条

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