A combinatorial approach towards 2-acyl-3-amino-indole derivatives

被引：10

作者：

Nettekoven, M ^{[1
]}

机构：

[1] F Hoffmann La Roche & Co Ltd, Pharmaceut Res, Chem Technol, Automated Chem, CH-4070 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 43期

关键词：

combinatorial chemistry; solution phase synthesis; indole derivative library; HPLC purification;

D O I：

10.1016/S0040-4039(00)01467-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A widely applicable reaction sequence towards functionalised 2-acyl-3-amino-indole derivatives is presented. A set of 205 indole derivatives were prepared, in a solution phase combinatorial fashion, by coupling a reliable reaction protocol to a rapid purification system employing parallel filtration and application of automated reversed phase HPLC. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8251 / 8254

页数：4

共 18 条

[1] AZOLE CHEMISTRY .5. SYNTHESIS AND SPECTRAL PROPERTIES OF THIAZOLO[3,2-D]TETRAZOLIUM SALTS [J].