The Collaborative Cross, a community resource for the genetic analysis of complex traits

被引：776

作者：

Churchill, G

Airey, DC

Allayee, H

Angel, JM

Attie, AD

Beatty, J

Beavis, WD

Belknap, JK

Bennett, B

Berrettini, W

Bleich, A

Bogue, M

Broman, KW

Buck, KJ

Buckler, E

Burmeister, M

Chesler, EJ

Cheverud, JM

Clapcote, S

Cook, MN

Cox, RD

Crabbe, JC

Crusio, WE

Darvasi, A

Deschnepper, CF

Doerge, RW

Farber, CR

Forejt, J

Gaile, D

Garlow, SJ

Geiger, H

Gershenfeld, H

Gordon, T

Gu, J

Gu, WK

de Haan, G

Hayes, NL

Heller, C

Himmelbauer, H

Hitzemann, R

Hunter, K

Hsu, HC

Iraqi, FA

Ivandic, B

Jacob, HJ

Jansen, RC

Jjepsen, KJ

Johnson, DK

Johnson, TE

Kempermann, G

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA

[3] Univ So Calif, Keck Sch Med, Los Angeles, CA USA

[4] Univ Texas, MD Anderson Canc Ctr, Sci Pk Res Div, Smithville, TX USA

[5] Univ Wisconsin, Dept Biochem, Madison, WI 53705 USA

[6] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA

[7] Natl Ctr Genome Resources, Santa Fe, NM USA

[8] Oregon Hlth & Sci Univ, Vet Affairs Med Ctr, Portland, OR 97201 USA

[9] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA

[10] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[11] Hannover Med Sch, Inst Lab Anim Sci & Cent Anim Facil, D-3000 Hannover, Germany

[12] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA

[13] Vet Affairs Med Ctr, Dept Behav Neurosci, Portland, OR USA

[14] Cornell Univ, Inst Genom Divers, Ithaca, NY USA

[15] Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI USA

[16] Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USA

[17] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

[18] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[19] Univ Memphis, Dept Psychol, Memphis, TN 38152 USA

[20] QTL & Modifier Loci Grp, MRC Mammalian Genet Unit, Harwell, Oxon, England

[21] Univ Massachusetts, Sch Med, Brudnick Neuropsychiat Res Inst, Worcester, MA USA

[22] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Evolut Systemat & Ecol, IL-91905 Jerusalem, Israel

[23] Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

[24] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA

[25] Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA

[26] ASCR, Inst Genet Mol, Videnska, Czech Republic

[27] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Biostat, Buffalo, NY 14260 USA

[28] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA

[29] Univ Cincinnati, Med Ctr, Div Expt Hematol, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45267 USA

[30] Univ Texas SW, Dallas, TX USA

[31] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY USA

[32] Univ Tennessee, Ctr Hlth Sci, Dept Orthopaed Surg Campbell Clin, Memphis, TN 38163 USA

[33] Univ Tennessee, Ctr Hlth Sci, Ctr Genom & Bioinformat, Dept Pathol, Memphis, TN 38163 USA

[34] Univ Tennessee, Ctr Hlth Sci, Ctr Dis Connect Tissues, Memphis, TN 38163 USA

[35] Univ Groningen, Dept Stem Cell Biol, NL-9700 AB Groningen, Netherlands

[36] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA

[37] Stanford Univ, Stanford, CA 94305 USA

[38] Max Planck Inst Mol Genet, Berlin, Germany

[39] NIH, Bethesda, MD 20892 USA

[40] Univ Alabama Birmingham, Clin Immunol & Rheumatol, Birmingham, AL USA

[41] Int Livestock Res Inst, Nairobi, Kenya

[42] Heidelberg Univ, Dept Med 3, Heidelberg, Germany

[43] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[44] Groningen Bioinformat Ctr, Inst Math & Comp Sci, Groningen, Netherlands

[45] Mt Sinai Sch Med, Dept Orthopaed, New York, NY USA

[46] Oak Ridge Natl Lab, Div Life Sci, Mammalian Genet Grp, Oak Ridge, TN USA

[47] Charite Univ Med Berlin, Max Delbruck Ctr Mol Med, Dept Expt Neurol, Berlin, Germany

[48] Univ Wisconsin, Med Sci Ctr, Dept Biostat & Med Informat, Madison, WI USA

[49] Univ Tennessee, Ctr Hlth Sci, Dept Surg, Memphis, TN 38163 USA

[50] Univ Tennessee, Ctr Hlth Sci, Dept Mol Sci, Memphis, TN 38163 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 11期

关键词：

D O I：

10.1038/ng1104-1133

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

引用

页码：1133 / 1137

页数：5

共 16 条

[1] Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains [J].