VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS)

被引：34

作者：

Terry, PD

Kamel, F

Umbach, DM

Lehman, TA

Hu, H

Sandler, DP

Taylor, JA

机构：

[1] NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[3] NIEHS, Biostat Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[6] BioServe Biotechnol Ltd, Laurel, MD 20707 USA

[7] NIEHS, Mol Carcinogenesis Lab, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF NEUROGENETICS | 2004年 / 18卷 / 02期

关键词：

vascular endothelial growth factor; amyotrophic lateral sclerosis; epidemiologic studies; haplotypes;

D O I：

10.1080/01677060490894450

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vascular endothelial growth factor (VEGF) is a cytokine essential for angiogenesis. A recent study found that haplotypes, determined by three SNPs (-2,578C/A, -1,154 G/A, and -634G/C) in the VEGF upstream promoter/leader sequence, were associated with risk of amyotrophic lateral sclerosis (ALS). We used samples and data from a case-control study to examine the relation of ALS to VEGF haplotype. Genotypes at each of the three polymorphic sites were determined using allele-specific primer extension reactions followed by MALDI-TOF. We found a 3-fold increased risk among individuals homozygous for the AAG or AGG haplotypes (95% CI=0.7-13.4), consistent with the findings of the previous study. Given the wide confidence interval, our findings should be interpreted cautiously.

引用

页码：429 / 434

页数：6

共 14 条

[1] VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model [J].