New oral anticoagulants in development

被引:88
作者
Weitz, Jeffrey I. [1 ,2 ,3 ]
机构
[1] Henderson Res Ctr, Hamilton, ON L8V 1C3, Canada
[2] McMaster Univ, Dept Med, Hamilton, ON, Canada
[3] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada
关键词
Anticoagulants; arterial thromboembolism; direct factor Xa inhibitors; direct thrombin inhibitors; venous thromboembolism; FACTOR-XA INHIBITOR; DEEP-VEIN THROMBOSIS; NONVALVULAR ATRIAL-FIBRILLATION; RIVAROXABAN BAY 59-7939; TOTAL KNEE REPLACEMENT; TOTAL HIP-REPLACEMENT; VENOUS THROMBOEMBOLISM; DABIGATRAN ETEXILATE; DOUBLE-BLIND; ANTITHROMBOTIC THERAPY;
D O I
10.1160/TH09-07-0434
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although currently available anticoagulants are effective for the prevention and treatment of thromboembolic disorders, they have several drawbacks. Low-molecular-weight heparins and fondaparinux produce a predictable level of anticoagulation that obviates the need for coagulation monitoring, but they must be given parenterally, which renders them inconvenient for long-term use. Vitamin K antagonists, such as warfarin, are administered orally, but produce a variable anticoagulant response because genetic polymorphisms, dietary vitamin K intake and multiple drug-drug interactions affect their metabolism. Consequently, coagulation monitoring and frequent dose adjustments are needed to ensure that a therapeutic level of anticoagulation is achieved. This is burdensome for patients and physicians, and costly for the healthcare system. These limitations have prompted the development of new oral anticoagulants that target thrombin or factor Xa and can be given in fixed doses without coagulation monitoring. This paper focuses on the new oral anticoagulants in the most advanced stages of development.
引用
收藏
页码:62 / 70
页数:9
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