Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey

被引:197
作者
Anderson, ME
Postupna, N
Ruffo, M
机构
[1] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA
[2] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA
[3] Univ Washington, Grad Program Neurobiol & Behav, Seattle, WA 98195 USA
[4] Univ Washington, Reg Primate Res Ctr, Seattle, WA 98195 USA
关键词
D O I
10.1152/jn.00475.2002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The reduction in symptoms of Parkinson's disease produced by high-frequency stimulation (HFS) in the internal globus pallidus (GPi) has been proposed to be due to stimulus-induced inactivation of pallidal neurons and resulting disinhibition of thalamic neurons. We tested this in awake Macaca fascicularis by stimulating between pairs of electrodes inserted into GPi under electrophysiological control and recording the responses evoked in thalamic neurons. HFS produced a reduction, not an increase, in discharge frequency during the stimulus train in 77% of the responsive thalamic neurons. Only 16% of the responsive cells showed an increase in discharge during stimulation and, for some of these, stimulation at a similar intensity produced contralateral muscle contraction, a probable sign of current spread to the internal capsule. The few thalamic neurons studied during bursting had a reduction in burst frequency and duration during HFS. We conclude that high-frequency stimulation within GPi does not necessarily facilitate thalamic discharge, and it may act, instead, to interrupt abnormal patterns of thalamic discharge associated with parkinsonian symptoms.
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收藏
页码:1150 / 1160
页数:11
相关论文
共 39 条
[1]   Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease [J].
Alegret, M ;
Junqué, C ;
Valldeoriola, F ;
Vendrell, P ;
Pilleri, M ;
Rumià, J ;
Tolosa, E .
ARCHIVES OF NEUROLOGY, 2001, 58 (08) :1223-1227
[2]   DISCHARGE PATTERNS OF BASAL GANGLIA NEURONS DURING ACTIVE MAINTENANCE OF POSTURAL STABILITY AND ADJUSTMENT TO CHAIR TILT [J].
ANDERSON, ME .
BRAIN RESEARCH, 1978, 143 (02) :325-338
[3]   Immediate motor effects of stimulation through electrodes implanted in the human globus pallidus [J].
Ashby, P ;
Strafella, A ;
Dostrovsky, JO ;
Lozano, A ;
Lang, AE .
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 1998, 70 (01) :1-18
[4]  
BAKER KB, 2001, SOC NEUR ABSTR, V27
[5]   Pallidal stimulation for Parkinson's disease - Two targets? [J].
Bejjani, B ;
Damier, P ;
Arnulf, I ;
Bonnet, AM ;
Vidailhet, M ;
Dormont, D ;
Pidoux, B ;
Cornu, P ;
Marsault, C ;
Agid, Y .
NEUROLOGY, 1997, 49 (06) :1564-1569
[6]  
BENABID AL, 1994, STEREOT FUNCT NEUROS, V62, P76, DOI 10.1159/000098600
[7]   RESPONSES OF SUBSTANTIA-NIGRA PARS RETICULATA AND GLOBUS-PALLIDUS COMPLEX TO HIGH-FREQUENCY STIMULATION OF THE SUBTHALAMIC NUCLEUS IN RATS - ELECTROPHYSIOLOGICAL DATA [J].
BENAZZOUZ, A ;
PIALLAT, B ;
POLLAK, P ;
BENABID, AL .
NEUROSCIENCE LETTERS, 1995, 189 (02) :77-80
[8]   REVERSAL OF RIGIDITY AND IMPROVEMENT IN MOTOR-PERFORMANCE BY SUBTHALAMIC HIGH-FREQUENCY STIMULATION IN MPTP-TREATED MONKEYS [J].
BENAZZOUZ, A ;
GROSS, C ;
FEGER, J ;
BORAUD, T ;
BIOULAC, B .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (04) :382-389
[9]   Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat [J].
Benazzouz, A ;
Gao, DM ;
Ni, ZG ;
Piallat, B ;
Bouali-Benazzouz, R ;
Benabid, AL .
NEUROSCIENCE, 2000, 99 (02) :289-295
[10]   THE PRIMATE SUBTHALAMIC NUCLEUS .2. NEURONAL-ACTIVITY IN THE MPTP MODEL OF PARKINSONISM [J].
BERGMAN, H ;
WICHMANN, T ;
KARMON, B ;
DELONG, MR .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (02) :507-520