A novel method using cyanobacteria for ecotoxicity test of veterinary antimicrobial agents

被引：91

作者：

Ando, Tomonori

Nagase, Hiroyasu

Eguchi, Kaoru

Hirooka, Takashi

Nakamura, Takanori

Miyamoto, Kazuhisa

Hirata, Kazumasa

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Environm Biotechnol, Suita, Osaka 5650871, Japan

[2] Natl Vet Assay Lab, Minist Agr Forestry & Fisheries, Tokyo 1858511, Japan

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2007年 / 26卷 / 04期

关键词：

antimicrobial agent; cyanobacterium; ecotoxicity test; algal toxicity; RESISTANCE MONITORING PROGRAM; WASTE-WATER BACTERIA; AQUATIC ENVIRONMENT; ANTIBIOTICS; BIODEGRADABILITY; SULFAMETHOXAZOLE; PHARMACEUTICALS;

D O I：

10.1897/06-195R.1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effect of antimicrobial agents for veterinary use on the growth of cyanobacteria was investigated by measuring minimum inhibitory concentration, medium effective concentration (EC50), and no-observed-effect concentration of seven antimicrobial agents for eight cyanobacteria. The results demonstrated that the seven antimicrobial agents, even at low concentrations, inhibited the growth of cyanobacteria. Microcystis aeruginosa and Synechococcus sp. had the highest sensitivity to the antimicrobial agents used in the present study. It is considered that the utilization of cyanobacteria would enable easy and highly sensitive assessment of the toxicity of such chemicals as antimicrobial agents. We suggest that cyanobacteria be used for ecotoxicity test in addition to the hitherto established method that uses green algae.

引用

页码：601 / 606

页数：6

共 24 条

[1] Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria [J].