Overexpression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development

被引：23

作者：

Zhu, Xuming ^{[1
]}

Wu, Yumei ^{[2
]}

Huang, Sixia ^{[1
]}

Chen, Yingwei ^{[2
]}

Tao, Yixin ^{[1
]}

Wang, Yushu ^{[1
]}

He, Shigang ^{[1
,3
]}

Shen, Sanbing ^{[1
,4
]}

Wu, Ji ^{[1
]}

Guo, Xizhi ^{[1
]}

Li, Baojie ^{[1
]}

He, Lin ^{[1
]}

Ma, Gang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Dermatol,Luwan Branch, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China

[4] Natl Univ Ireland Galway, Regenerat Med Inst, Sch Med, Galway, Ireland

来源：

EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 12期

基金：

上海市自然科学基金;

关键词：

hair cycle; psoriasis; Wnt5a; -catenin; STEM-CELLS; EXPRESSION; MORPHOGENESIS; SKIN; MICE;

D O I：

10.1111/exd.12539

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression under the control of the human K14 promoter. The skin of Wnt5a TG mice was not psoriatic, but characterized with normal proliferation and homeostasis of epidermis. Instead, these TG mice displayed impaired hair follicle transition from telogen to anagen, most likely due to impaired canonical Wnt signalling. These results suggest that increased Wnt5a expression alone is inadequate to induce psoriasis in the skin and possible involvement of Wnt5a in hair follicle cycling.

引用

收藏

页码：926 / 928

页数：3

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