BEDSIDE TO BENCH The emerging epithelium

被引：34

作者：

Lloyd, Clare M. ^{[1
,2
]}

Saglani, Sejal ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, UK Med Res Council, Leukocyte Biol Sect, London, England

[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Asthma UK Ctr Allerg Mech Asthma, London, England

来源：

NATURE MEDICINE | 2010年 / 16卷 / 03期

基金：

英国惠康基金;

关键词：

ASTHMA; MEPOLIZUMAB; CELLS;

D O I：

10.1038/nm0310-273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thinking about how asthma and allergic diseases arise is undergoing several shifts. In 'Bedside to Bench', Clare M. Lloyd and Sejal Saglani examine how recent human studies are putting the focus on the epithelium as a major contributor to asthma. The findings shift the emphasis away from the T helper type 2 immune response, and call into question the utility of current animal models of the disease. Although asthma and other allergic disorders are known to have origins in infancy, some researchers are looking even earlier, to effects in utero and before conception. In 'Bench to Bedside', Catherine Hawrylowicz and Kimuli Ryanna highlight animal studies that outline some of the effects of the maternal environment, and they examine the potential implications for prevention of disease.

引用

页码：273 / 274

页数：2