Human autoimmunity genes in mice

被引：15

作者：

Fugger, L ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Skejby Sygehus, Dept Clin Immunol, DK-8200 Aarhus N, Denmark

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(00)00165-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the post-genomic era, the expression and investigation of human (auto)immunity genes seems more relevant than ever. The generation of humanized animal models of human diseases will be useful to study the interplay between genetic and nongenetic factors in disease development and may form a basis for the development of new drugs that act more specifically than the ones currently in use. Transgenic mice have been generated that express various human proteins - candidate autoantigens, disease-associated MHC class II molecules, TCRs and/or CD4 - in order to study diseases such as rheumatoid arthritis, multiple sclerosis and diabetes.

引用

页码：698 / 703

页数：6

共 53 条

[1] Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice [J].

Abraham, RS ;

David, CS .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) :122-129

[2] Definition of MHC and T cell receptor contacts in the HLA-DR4-restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice [J].

Andersson, EC ;

Hansen, BE ;

Jacobsen, H ;

Madsen, LS ;

Andersen, CB ;

Engberg, J ;

Rothbard, JB ;

McDevitt, GS ;

Malmström, V ;

Holmdahl, R ;

Svejgaard, A ;

Fugger, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7574-7579

[3]

Cook AD, 1999, ARTHRITIS RHEUM, V42, P2569, DOI 10.1002/1529-0131(199912)42:12<2569::AID-ANR9>3.0.CO

[4]

2-3

[5] MICE LACKING MHC CLASS-II MOLECULES [J].

COSGROVE, D ;

GRAY, D ;

DIERICH, A ;

KAUFMAN, J ;

LEMEUR, M ;

BENOIST, C ;

MATHIS, D .

CELL, 1991, 66 (05) :1051-1066

[6]

de Vries N, 1999, ARTHRITIS RHEUM, V42, P1621, DOI 10.1002/1529-0131(199908)42:8<1621::AID-ANR9>3.0.CO

[7]

2-0

[8] X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II [J].

Dessen, A ;

Lawrence, CM ;

Cupo, S ;

Zaller, DM ;

Wiley, DC .

IMMUNITY, 1997, 7 (04) :473-481

[9] The HLA-DQ7 and -DQ8 associations in DR4-positive rheumatoid arthritis patients - A combined analysis of data available in the literature [J].

Fugger, L ;

Svejgaard, A .

TISSUE ANTIGENS, 1997, 50 (05) :494-500

[10] Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen [J].

Fugger, L ;

Rothbard, JB ;

SonderstrupMcDevitt, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :928-933

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