Exploiting the defensive sugars of HIV-1 for drug and vaccine design

被引：204

作者：

Scanlan, Christopher N.

Offer, John

Zitzmann, Nicole

Dwek, Raymond A.

机构：

[1] Univ Oxford, Glycobiol Inst, Oxford OX1 3QU, England

[2] Univ Oxford, Scripps Oxford Lab, Dept Biochem, Oxford OX1 3QU, England

来源：

NATURE | 2007年 / 446卷 / 7139期

关键词：

D O I：

10.1038/nature05818

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.

引用

页码：1038 / 1045

页数：8

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