Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era

被引：15

作者：

Britton, RA

Chen, SM

Wallis, D

Koeuth, T

Powell, BS

Shaffer, LG

Largaespada, D

Jenkins, NA

Copeland, NG

Court, DL

Lupski, JR ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[3] NCI, Frederick Canc Res & Dev Ctr, DBS, Moust Canc Genet Program, Frederick, MD 21702 USA

来源：

GENOMICS | 2000年 / 67卷 / 01期

关键词：

D O I：

10.1006/geno.2000.6243

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Era is an essential GTPase that is required for proper cell cycle progression and cell division in Escherichia coli and is found in nearly all bacteria sequenced to date. To determine whether Era is also present in eukaryotic organisms, we searched the dbEST database and found EST clones coding for proteins that were similar to Era. Full sequencing of these ESTs from human and mouse identified a conserved homologue, ERAL1 (Era-like I). ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome II. ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region Ts here loss of heterozygosity is often associated with various types of cancer. (C) 2000 Academic Press.

引用

页码：78 / 82

页数：5