Should hepatitis B vaccination be introduced into childhood immunisation programmes in northern Europe?

被引:66
作者
Zuckerman, Jane
van Hattum, Jan
Cafferkey, Mary
Gjorup, Ida
Hoel, Terje
Rummukainen, Maija-Liisa
Weiland, Ola
机构
[1] UCL Royal Free & Univ Coll, Sch Med, Acad Ctr Travel Med & Vaccines, WHO Collaborating Ctr Travel Med, London NW3 2PF, England
[2] Beatrix Hosp, Dept Gastroenterol, Gorinchem, Netherlands
[3] Natl Hepatitis Ctr, Amersfoort, Netherlands
[4] Rotunda Hosp, Dept Microbiol, Dublin, Ireland
[5] Univ Copenhagen, Herlev Hosp, Dept Med, Copenhagen, Denmark
[6] Ullevaal Univ Hosp, Dept Infect Dis, Oslo, Norway
[7] Jyvaskyla Cent Hosp, Dept Med, Jyvaskyla, Finland
[8] Karolinska Univ, Huddinge Hosp, Div Infect Dis, Stockholm, Sweden
关键词
D O I
10.1016/S1473-3099(07)70136-6
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Infection with hepatitis B causes between 500 000 and 1 center dot 2 million deaths per year worldwide, and is the leading cause of liver cancer. Over 12 years ago, WHO recommended that universal childhood hepatitis B vaccination be implemented globally. Despite this, Denmark, Finland, Iceland, Ireland, the Netherlands Norway, Sweden, and the UK have yet to implement such a policy and instead currently adopt an "at-risk" strategy. Although all eight countries are classed as having low endemicity, factors such as increased travel and integration of immigrant communities are increasing the number of at-risk individuals in these countries. Considering the difficulty in identifying all at-risk individuals, and the lack of effectiveness of at-risk vaccination on reducing the overall incidence of hepatitis B, we recommend that these countries reassess their hepatitis B prevention strategies. Universal vaccination against hepatitis B is the only way to eliminate the major public-health impact of this disease.
引用
收藏
页码:410 / 419
页数:10
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