The dual nature of TH17 cells: shifting the focus to function

被引：142

作者：

O'Connor, William, Jr. ^{[1
]}

Zenewicz, Lauren A. ^{[1
]}

Flavell, Richard A. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06511 USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 06期

关键词：

REGULATORY T-CELLS; ROR-GAMMA-T; TRANSCRIPTION FACTOR FOXP3; GROWTH-FACTOR-BETA; INDUCER-LIKE CELLS; HOST-DEFENSE; TH17; CELLS; TGF-BETA; INTESTINAL INFLAMMATION; DIFFERENTIAL ROLES;

D O I：

10.1038/ni.1882

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) have been broadly linked to the pathogenesis of multiple autoimmune diseases. In the few short years since the discovery of T(H)17 cells, new paradigms about their prominence in chronic inflammation and human autoimmunity have emerged. Recent findings that T(H)17 cells might be capable of regulatory functions and that the associated effector molecules IL-17 and IL-22 aid in restricting tissue destruction during inflammatory episodes illuminate the complexities of IL-17 and T(H)17 biology. In this Perspective we highlight critical differences between IL-17 itself and T(H)17 cells and discuss the protective nature of IL-17 and T(H)17 cells.

引用

页码：471 / 476

页数：6

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