The influence of neuropathology on the fMRI signal: A measurement of brain or vein?

被引：26

作者：

Hillary, F. G. ^{[1
]}

Biswal, B.

机构：

[1] Penn State Univ, Dept Psychol, State Coll, PA 16804 USA

[2] Univ Med & Dent New Jersey, Dept Radiol, Newark, NJ 07103 USA

来源：

CLINICAL NEUROPSYCHOLOGIST | 2007年 / 21卷 / 01期

关键词：

blood flow; CBF; fMRI; functional imaging; lesions; TBI;

D O I：

10.1080/13854040601064542

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

There is a rapid v growing literature using fMRI technology to investigate the various forms of behavioral impairment associated with brain injury and disease. Given this, surprisingly little work has been conducted to examine the influence of neuropathophysiological processes on the fMRI signal. This paper reviews the literature examining baseline alteration in cerebrovascular parameters associated with normal aging, brain injury, and brain disease. In addition, findings from three cases of individuals with severe brain trauma will be presented to show the influence of brain trauma on baseline cerebro vascular parameters measured by fMRI. The methods used here can be implemented by other investigators to accurately isolate specific hemodynamic changes that can influence the BOLD fMRI signal.

引用

页码：58 / 72

页数：15

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