Chloropalladated propargyl amine: A highly efficient phosphine-free catalyst precursor for the Heck reaction

被引：134

作者：

Consorti, CS ^{[1
]}

Zanini, ML ^{[1
]}

Leal, S ^{[1
]}

Ebeling, G ^{[1
]}

Dupont, J ^{[1
]}

机构：

[1] UFRGS, IQ, Lab Mol Catalysis, BR-91501970 Porto Alegre, RS, Brazil

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 07期

关键词：

D O I：

10.1021/ol027337l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] The palladacycle {Pd[k(1)-C, k(1)-N-C=(C6H5)C(Cl)CH2NMe2](mu-Cl)}(2) 1 derived from the chloropalladation of 3-(dimethylamino)-1-phenyl-1-propyne promotes the arylation of olefins under relatively mild reaction conditions. The coupling of iodoarenes and activated bromoarenes with n-butylacrylate and styrene occurs at room temperature. Turnover numbers of up to 85 000 have been achieved with deactivated bromoarenes and up to 1000 for activated chloroarenes at higher temperatures (80-150 degreesC).

引用

页码：983 / 986

页数：4

共 35 条

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