Matrix metalloproteinases and the regulation of tissue remodelling

被引：2275

作者：

Page-McCaw, Andrea ^{[1
]}

Ewald, Andrew J.

Werb, Zena

机构：

[1] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA

[2] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA

[3] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Program Biomed Sci, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 03期

关键词：

D O I：

10.1038/nrm2125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Matrix metalloproteinases ( MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

引用

页码：221 / 233

页数：13

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