Trichothecenes: reference materials and method validation

被引：36

作者：

Josephs, RD ^{[1
]}

Derbyshire, M ^{[1
]}

Stroka, J ^{[1
]}

Emons, H ^{[1
]}

Anklam, E ^{[1
]}

机构：

[1] Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements, B-2440 Geel, Belgium

来源：

TOXICOLOGY LETTERS | 2004年 / 153卷 / 01期

关键词：

deoxynivalenol; trichothecenes; mycotoxin; analysis; method validation; certified reference materials; CRM;

D O I：

10.1016/j.toxlet.2004.04.028

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The frequent contamination of food and feed with trichothecene mycotoxins, the high consumption of these products, and the potential risk associated herewith, has led to an increasing public awareness and therefore to the establishment of measures to control trichothecene contamination. The analytical difficulty and the economic importance of controlling trichothecenes in food and feed support the need for certified reference materials (CRMs) and validated methods. They form invaluable tools to ensure comparability and traceability in analytical measurements and are very useful for the implementation of written standards, legislation/regulations and laboratory accreditation. The present paper provides an overview of previous work, current strategies and prospectives for the production of CRMs and validation of analytical methods in the field of trichothecene analysis. Additional information is given on methodological demands, normative frameworks and commonly accepted procedures. (C) 2004 ILSI. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：123 / 132

页数：10

共 46 条

[41] WORLDWIDE CONTAMINATION OF CEREALS BY THE FUSARIUM MYCOTOXINS NIVALENOL, DEOXYNIVALENOL, AND ZEARALENONE .1. SURVEY OF 19 COUNTRIES [J].