MAGUK proteins:: structure and role in the tight junction

被引：380

作者：

González-Mariscal, L ^{[1
]}

Betanzos, A ^{[1
]}

Avila-Flores, A ^{[1
]}

机构：

[1] CINVESTAV, Ctr Res & Adv Studies, Dept Physiol Biophys & Neurosci, Mexico City 07000, DF, Mexico

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2000年 / 11卷 / 04期

关键词：

MAGUK; tight junction; ZO-1; ZO-2; ZO-3;

D O I：

10.1006/scdb.2000.0178

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK), ZOs have a distinctive carboxyl terminal with splicing domains, acidic- and proline-rich regions. The modular organization of these proteins allows them to function as scaffolds, which associate to transmembrane TJ proteins, the cytoskeleton and signal transduction molecules. ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression.

引用

页码：315 / 324

页数：10

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