ACCURATE AUTOMATIC DELINEATION OF HETEROGENEOUS FUNCTIONAL VOLUMES IN POSITRON EMISSION TOMOGRAPHY FOR ONCOLOGY APPLICATIONS

被引:147
作者
Hatt, Mathieu [1 ]
le Rest, Catherine Cheze [2 ]
Descourt, Patrice
Dekker, Andre [3 ]
De Ruysscher, Dirk [3 ]
Oellers, Michel [3 ]
Lambin, Philippe [3 ]
Pradier, Olivier [4 ]
Visvikis, Dimitris
机构
[1] INSERM, LATIM, CHU MORVAN, U650, F-29609 Brest, France
[2] CHU Brest, F-29285 Brest, France
[3] MAASTricht Radiat Oncol Clin, Maastricht, Netherlands
[4] Ctr Hosp Univ Morvan, Inst Oncol, Brest, France
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 77卷 / 01期
关键词
Heterogeneous functional volumes delineation; Automatic segmentation; Image-guided radiotherapy; Dose painting; PET; RADIOTHERAPY; DEFINITION; TUMOR; SEGMENTATION; TARGET; CANCER; INTEROBSERVER; IMAGES;
D O I
10.1016/j.ijrobp.2009.08.018
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Accurate contouring of positron emission tomography (PET) functional volumes is now considered crucial in image-guided radiotherapy and other oncology applications because the use of functional imaging allows for biological target definition. In addition, the definition of variable uptake regions within the tumor itself may facilitate dose painting for dosimetry optimization. Methods and Materials: Current state-of-the-art algorithms for functional volume segmentation use adaptive thresholding. We developed an approach called fuzzy locally adaptive Bayesian (FLAB), validated on homogeneous objects, and then improved it by allowing the use of up to three tumor classes for the delineation of inhomogeneous tumors (3-FLAB). Simulated and real tumors with histology data containing homogeneous and heterogeneous activity distributions were used to assess the algorithm's accuracy. Results: The new 3-FLAB algorithm is able to extract the overall tumor from the background tissues and delineate variable uptake regions within the tumors, with higher accuracy and robustness compared with adaptive threshold (T-bckg) and fuzzy C-means (FCM). 3-FLAB performed with a mean classification error of less than 9% +/- 8% on the simulated tumors, whereas binary-only implementation led to errors of 15% +/- 11%. T-bckg and FCM led to mean errors of 20% +/- 12% and 17% +/- 14%, respectively. 3-FLAB also led to more robust estimation of the maximum diameters of tumors with histology measurements, with <6% standard deviation, whereas binary FLAB, T-bckg and FCM lead to 10%, 12%, and 13%, respectively. Conclusion: These encouraging results warrant further investigation in future studies that will investigate the impact of 3-FLAB in radiotherapy treatment planning, diagnosis, and therapy response evaluation. (C) 2010 Elsevier Inc.
引用
收藏
页码:301 / 308
页数:8
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