Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus

被引:220
作者
Wandstrat, AE
Nguyen, C
Limaye, N
Chan, AY
Subramanian, S
Tian, XH
Yim, YS
Pertsemlidis, A
Garner, HR
Morel, L
Wakeland, EK
机构
[1] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Eugene McDermott Ctr Human Growth & Dev, Dallas, TX 75235 USA
[3] Univ Florida, Sch Med, Dept Pathol & Lab Med, Gainesville, FL 32611 USA
关键词
D O I
10.1016/j.immuni.2004.10.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Susceptibility to autoimmunity in B6.Sie1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sie1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57BI/6 (136) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sie1b mice. T lymphocytes from B6.Sielb mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly1OB, a specific isoform of which is constitutively upregulated in B6.Sie1b lymphocytes.
引用
收藏
页码:769 / 780
页数:12
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