Pre-implantation genetic diagnosis

被引:9
作者
Delhanty, JDA [1 ]
Harper, JC [1 ]
机构
[1] UCL, Dept Obstet & Gynaecol, London WC1E 6HX, England
关键词
pre-implantation diagnosis; genetics; embryo biopsy; FISH; PCR;
D O I
10.1053/beog.2000.0105
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Pre-implantation genetic diagnosis (PGD) was developed in the UK over 10 years ago. There are now more than 40 centres worldwide carrying out PGD and 150 babies have been born after genetic testing on day 3 of development, at the cleavage stage. This review-covers the current status of PGD, the technology used and the types of genetically determined diseases for which testing has been developed.
引用
收藏
页码:691 / 708
页数:18
相关论文
共 71 条
[2]   Preimplantation genetic diagnosis of inherited cancer: Familial adenomatous polyposis coli [J].
Ao, A ;
Wells, D ;
Handyside, AH ;
Winston, RML ;
Delhanty, JDA .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1998, 15 (03) :140-144
[3]   Management of rhesus isoimmunization by preimplantation genetic diagnosis [J].
Avner, Rachel ;
Reubinoff, Benjamin E. ;
Simon, Alex ;
Zentner, Bat-Sheva ;
Friedmann, Adam ;
Mitrani-Rosenbaum, Stella ;
Laufer, Neri .
MOLECULAR HUMAN REPRODUCTION, 1996, 2 (01) :60-62
[4]   Preimplantation genetic diagnosis of human embryos for Marfan's syndrome [J].
Blaszczyk, A ;
Tang, YX ;
Dietz, HC ;
Adler, A ;
Berkeley, AS ;
Krey, LC ;
Grifo, JA .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1998, 15 (05) :281-284
[5]   Successful use of a laser for human embryo biopsy in preimplantation genetic diagnosis: Report of two cases [J].
Boada, M ;
Carrera, M ;
De la Iglesia, C ;
Sandalinas, M ;
Barri, PN ;
Veiga, A .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1998, 15 (05) :302-307
[6]   Infertile couples with Robertsonian translocations: preimplantation genetic analysis of embryos reveals chaotic cleavage divisions [J].
Conn, CM ;
Harper, JC ;
Winston, RML ;
Delhanty, JDA .
HUMAN GENETICS, 1998, 102 (01) :117-123
[7]  
Conn CM, 1999, J MED GENET, V36, P45
[8]   A trisomic germ cell line and precocious chromatid segregation leads to recurrent trisomy 21 conception [J].
Cozzi, J ;
Conn, CM ;
Harper, J ;
Winston, RML ;
Rindl, M ;
Farndon, PA ;
Delhanty, JDA .
HUMAN GENETICS, 1999, 104 (01) :23-28
[9]   Pregnancy after preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A [J].
De Vos, A ;
Sermon, K ;
Van de Velde, H ;
Joris, H ;
Vandervorst, M ;
Lissens, W ;
Mortier, G ;
De Sutter, P ;
Lofgren, A ;
Van Broeckhoven, C ;
Liebaers, I ;
Van Steirteghem, A .
MOLECULAR HUMAN REPRODUCTION, 1998, 4 (10) :978-984
[10]   DETECTION OF ANEUPLOIDY AND CHROMOSOMAL MOSAICISM IN HUMAN EMBRYOS DURING PREIMPLANTATION SEX DETERMINATION BY FLUORESCENT IN-SITU HYBRIDIZATION, (FISH) [J].
DELHANTY, JDA ;
GRIFFIN, DK ;
HANDYSIDE, AH ;
HARPER, J ;
ATKINSON, GHG ;
PIETERS, MHEC ;
WINSTON, RML .
HUMAN MOLECULAR GENETICS, 1993, 2 (08) :1183-1185