Systematic discovery of new genes in the Saccharomyces cerevisiae genome

被引：48

作者：

Kessler, MM ^{[1
]}

Zeng, QD ^{[1
]}

Hogan, S ^{[1
]}

Cook, R ^{[1
]}

Morales, AJ ^{[1
]}

Cottarel, G ^{[1
]}

机构：

[1] Genome Therapeut Corp, Waltham, MA 02453 USA

来源：

GENOME RESEARCH | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1101/gr.232903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for small open reading frames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.

引用

页码：264 / 271

页数：8

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