Genomic Exploration of the Hemiascomycetous Yeasts:: 4.: The genome of Saccharomyces cerevisiae revisited

被引：71

作者：

Blandin, G

Durrens, P

Tekaia, F

Aigle, M

Bolotin-Fukuhara, M

Bon, E

Casarégola, S

de Montigny, J

Gaillardin, C

Lépingle, A

Llorente, B

Malpertuy, A

Neuvéglise, C

Ozier-Kalogeropoulos, O

Perrin, A

Potier, S

Souciet, JL

Talla, E

Toffano-Nioche, C

Wésolowski-Louvel, M

Marck, C

Dujon, B

机构：

[1] CNRS, URA 2171, Unite Genet Mol Levures, F-75724 Paris 15, France

[2] Univ Paris 06, Inst Pasteur, UFR 927, F-75724 Paris 15, France

[3] IBGC, Lab Biol Cellulaire Levure, F-33077 Bordeaux, France

[4] Univ Paris Sud, CNRS, UMR 8621, Inst Mol Genet, F-91405 Orsay, France

[5] INA PG, CNRS,URA 1925, INRA,UMR216, Lab Genet Mol & Cellulaire,Collect Levures Intere, F-78850 Thiverval Grignon, France

[6] ULP, CNRS, UPRES A 7010, Lab Genet & Mol,Inst Bot, F-67000 Strasbourg, France

[7] Univ Lyon 1, CNRS, ERS2009, INSA, F-69622 Villeurbanne, France

[8] CEA Saclay, DSV, Dept Biol Cellulaire & Mol, Serv Biochim & Genet Mol, F-91191 Gif Sur Yvette, France

来源：

FEBS LETTERS | 2000年 / 487卷 / 01期

关键词：

annotation; pseudogene; intron; frameshift; family;

D O I：

10.1016/S0014-5793(00)02275-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its completion more than 4 years ago, the sequence of Saccharomyces cervisiae has been extensively used and studied. The original sequence has received a few corrections, and the identification of genes has been completed, thanks in particular to transcriptome analyses and to specialized studies on introns, tRNA genes, transposons or multigene families. In order to undertake the extensive comparative sequence analysis of this program, we have entirely revisited the S. cerevisiae sequence using the same criteria for all 16 chromosomes and taking into account publicly available annotations for genes and elements that cannot be predicted. Comparison with the other yeast species of this program indicates the existence of 50 novel genes in segments previously considered as 'intergenic' and suggests extensions for 26 of the previously annotated genes. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：31 / 36

页数：6

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